Drug-resistance management results presented at two symposia at MIM in Senegal

Maciek Boni Drug Resistance, Global Health, Malaria

We presented some of our most recent modeling results on how to effectively manage resistance to multiple artemisinin combination therapies (ACTs) at two symposia at the 7th Multilateral Initiative on Malaria (MIM) Pan-African Malaria Conference.  One symposium was run by our partners at Medicines for Malaria Venture (MMV) and a second one was run by Guilin Pharmaceuticals who are awaiting …

Postdoctoral positions open in malaria microsimulation

Maciek Boni Malaria

The Boni Lab in the Department of Biology at The Pennsylvania State University is recruiting highly-motivated postdoctoral scholars to work on several key public health questions using large-scale individual-based malaria simulations.   Our lab’s research interests can be seen here and here.   Positions can begin anytime in 2017. Our lab is based at the Center for Infectious Disease Dynamics …

Tran Thi Thanh Phuong passes her Oxford DPhil viva

Maciek Boni Economic Epidemiology, Malaria

Congratulations to Phuong on passing her DPhil viva on December 14! Phuong started working at OUCRU as a health economist in 2012, enrolled in Oxford’s DPhil program, and has been working on two major health economics questions for her DPhil studies.   Phuong looked at the costs and benefits of delayed versus immediate antiretroviral therapy of HIV+ tuberculosis-meningitis patients in …

Interrupted feeding analysis presented at WHO meeting

Maciek Boni Malaria, Recombination

On December 10-11, the WHO Technical Expert Group (TEG) on Drug Efficacy and Response met in Geneva to make recommendations on the appropriate response to the spread of artemisinin resistance, and to look at the effects of future malaria control strategies such as seasonal malaria chemoprophylaxis, triple combination therapies, and the deployment of multiple first-line therapies (MFT). The results of …

Multiple first-line artemisinin combination therapies

Maciek Boni Malaria

One of the earliest mathematical modeling questions our group began working concerned how we should best deploy antimalarial therapies to delay the onset of drug resistance for as long as possible.   This is a “resistance management” problem, and you can find some of the earliest publications on this topic here and here.   This work was led by Tran …

OUCRU’s first two mathematical modeling PhDs

Maciek Boni Influenza, Malaria

Congratulations to Dao Nguyen Vinh (left) and Tran Dang Nguyen (right) who both passed their PhD vivas this month. Vinh and Nguyen were the first two students in OUCRU’s mathematical modeling group, and they helped build the group up to its current state today, with seven people working on influenza and four on malaria. Vinh’s thesis was titled Influenza in …

Twenty years of artemisinin use in Vietnam

Maciek Boni Malaria

In the late 1980s, Vietnam experienced a large malaria resurgence resulting from the spread of chloroquine resistance and a strained public health system suffering from slow economic growth during the post-war rebuilding effort.   In 1991 and 1992 there were more than a million clinical malaria cases per year in Vietnam, with 4503 deaths in 1991 and 2669 deaths in …